After completing doctoral studies at the University of Maryland Baltimore and a postdoctoral fellowship at the National Cancer Institute, Dr. Susan Dorsey joined the University of Maryland School of Nursing faculty in 2004 where she is currently Associate Dean of Research and an Associate Professor. Dr. Dorsey holds an adjunct appointment in the Department of Neural & Pain Sciences in the School of Dentistry, is a full faculty member in the Marlene and Stewart Greenebaum Cancer Center, and is an active faculty member in several campus-wide Programs including Oncology, Neuroscience, and Genetics and Genomic Medicine.
Dr. Dorsey’s basic and translational program of research in the molecular, cellular and genetic mechanisms underlying the development and persistence of chronic pain has been continuously funded by the National Institutes of Health and the American Pain Society. She is the PI of the NINR P30 funded UM Center for Pain Studies. Her currently funded R01 supports pre-clinical mechanistic and intervention studies designed to identify new therapeutic targets that can be used to improve or ameliorate antiretroviral-associated neuropathic pain. Her most recent project, ARRA-funded, addresses molecular signaling associated with pain and neuromuscular dysfunction in muscular dystrophy.
In addition to being the PI of the University of Maryland Center for Pain Studies, Dr. Dorsey serves as a mentor for Naomi Horiba's pilot project Clinical study of chemotherapy-induced peripheral neuropathy pain and Cynthia Renn’s pilot project Pre-clinical study of chemotherapy-induced peripheral neuropathy pain.
PUBLICATIONS (most recent):
- Bao T, Lao L, Medeiros M, Zhang R, Dorsey SG and Badros A (in press). Improvement of painful bortezomib-induced peripheral neuropathy following acupuncture treatment in a case series of multiple myeloma patients. Medical Acupuncture.
- Cavaletti G, Cornblath D, Merkies I, Postma T, Rossi E et al and the CI-PERINOMS Study Group (2012). The chemotherapy-induced peripheral neuropathy outcome measures standardization (CI-PeriNomS) study: from consensus to the first validity and reliability findings. Annals of Oncology, Aug 21 [epub ahead of print].
- Wang X, Lehky TJ, Brell JM and Dorsey SG (2012). Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy. Cytokine, 59, 3-9.
- Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen Y-W, Raiteri R, Lederer WJ, Dorsey SG and Ward CW (2012). Microtubules underlie dysfunction in duchenne muscular dystrophy. Sci Signal, 5(236): ra56.
- Dorsey SG, Lovering RM, Renn CL, Leitch CC, Liu X et al (2012). Genetic deletion of trkB.T1 increases neuromuscular function. Am J Physiol Cell Physiol, 302, C141-C153.
- Mei Y, Liao J, Shen J, Yu L, Liu B, Liu L, Li R, Ji L, Dorsey SG, Jiang Z, Katz RL, Wang J-Y and Jiang F (2011). Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis. Oncogene.
- Renn CL, Leitch C, Lessans S, Rhee P, McGuire W, Smith B, Traub R and Dorsey SG (2011). Brain-derived neurotrophic factor modulates antiretroviral-induced mechanical allodynia in the mouse. Journal of Neuroscience Research, 89, 1551-1565.
- Ayala VI, Teijaro JR, Farber DL, Dorsey SG and Carbonetti NH (2011). Bordetella pertussis infection exacerbates influenza virus through pertussis toxin activity. PLoS ONE, Apr 20;6(4):e19016.
- Renn CL, Carozzi VA, Rhee P, Gallop D, Dorsey SG and Cavaletti G (2011). Multimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in mice. Molecular Pain Apr 26;7:29.
- Resnick B, Galik E, Dorsey S, Scheve A and Gutkin S (2011). Reliability and validity testing of the Physical Resilience Measure. Gerontologist, 51(5):643-652.
- Renn CL, Leitch CC and Dorsey SG (2009). In vivo evidence that truncated trkB.T1 participates in nociception. Molecular Pain, 29, 61.
- Dorsey SG, Leitch CC, Renn CL, Lessans S, Smith BA, Wang XM and Dionne RA (2009). Genome-wide screen identifies drug-induced regulation of the Giant Axonal Neuropathy (Gan) in a mouse model of antiretroviral-induced painful peripheral neuropathy. Biological Research for Nursing, 11, 7-16.
- Carim-Todd L, Bath K, Fulgenzi G, Yanpallewar S, Jing D, Barrick C, Becker J, Buckley H, Dorsey SG, Lee F and Tessarollo L (2009). Endogenous truncated trkB.T1 receptor regulates neuronal complexity and trkB kinase receptor function in vivo. Journal of Neuroscience, 29, 678-685.
- Dorsey SG, Renn CL, Carim-Todd L, Barrick CA, Bambrick LL, Krueger BK, Ward CW and Tessarollo T (2006). In vivo restoration of physiological levels of truncated trkBT1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron, 51, 21-28§. § Highlighted in Previews (Castren E and Tanila H (2006) Neuron 51:1-3)
- Renn CL, Lin L, Thomas S and Dorsey SG (2006). Full-length tropomyosin-related kinase B expression in the brainstem in response to persistent inflammatory pain. Neuroreport, 17, 1175-1179.
Title: Center for the Genomics of Pain
Co-MPIs: Faden and Dorsey
Title: Spinal Mechanisms Underlying SCI-Induced Pain: Implications for Targeted Therapy
Principal Investigator: Sweatt; Co-Investigator: Dorsey
Title: Epigenetic modifications of BDNF and trkB genes underlie pain plasticity
Director/Principal Investigator: Dorsey
Title: UM Center for Pain Studies
1R01NR010207 06/18/2007-03/31/2013 (NCE)
Principal Investigator: Dorsey
Title: BDNF Signal Strength Modulates NRTI-induced Allodynia in Mouse