Pilot Projects

Joan Davenport, PhD, RN
Senior Pilot Mentor: Deborah B. McGuire, PhD, RN, FAAN

  • Incidence, clinical features, and biological correlates of oral mucositis-related pain in patients with cancer of the esophagus or gastro-esophageal junction receiving combined chemo-radiation
  • Purpose: Identify the incidence, clinical features, and biological correlates of oral mucositis-related pain in a prospective study of patients with cancer of the esophagus and gastro-esophageal junction who are receiving combined chemo-radiation

 

Kathleen Griffith, PhD, CRNP
Senior Pilot Mentor: Charlene Hafer-Macko, MD

  • Features of painful peripheral neuropathy in patients following cancer treatment
  • Purpose: Characterize the painful cancer treatment-induced peripheral neuropathy experience in patients during the first year following completion of chemotherapy with cisplatin and/or paclitaxel (both agents are used in various malignancies and have different mechanisms of cytotoxicity and peripheral nerve damage

 

Naomi Horiba, MD, MPH
Senior Pilot Mentor: Susan G. Dorsey, PhD, RN

  • Incidence, quantitative sensory testing changes, gene expression, and psychosocial correlates of oxaliplatin-induced painful peripheral neuropathy in cancer patients
  • Purpose: Examine the pain experience in patients with colorectal cancer that receive oxaliplatin therapy and correlate the development and persistence of pain with quantitative sensory changes in thermal and mechanical thresholds and systemic gene expression

 

Cynthia L. Renn, PhD, RN
Senior Pilot Mentors: Susan G. Dorsey, PhD, RN & Christopher W. Ward, PhD

  • Mechanisms underlying oxaliplatin-induced nocifensive behaviors in the mouse
  • Purpose: Recapitulate the preclinical model of oxaliplatin-induced painful peripheral neuropathy in the mouse and quantify mechanical and thermal thresholds, peripheral sensory fiber innervation patterns, gene expression, and in an exploratory aim, response to aerobic exercise

 

Vanessa Anseloni, PsyD, PhD
Senior Pilot Mentors: Sharon Gordon, DDS, MPH, PhD & Richard Traub, PhD

  • Molecular mechanisms of mucositis in a preclinical model
  • Purpose: Demonstrate mucositis-induced visceral hypersensitivity and determine if this is correlated with an increase in inflammatory cytokines in the periphery and inflammation-induced changes in microglial activation and inflammatory cytokine production in the spinal cord